Bottom Line Up Front (BLUF): How to Dispose of Medicine Safely To safely dispose of expired or unused medication, follow these three steps in order of preference: Drug Take-Back Sites: Use a DEA-authorized collection site or a pharmacy drop box (safest). The Flush List: Only flush medications (like Opioids) specifically listed on the FDA Flush List. Household Trash: Mix pills with unappealing substances (coffee grounds/kitty litter) in a sealed bag; do not crush them. Profess